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Education:

Sep ’12 - Dec ‘17 - Ph.D. (Marrone Lab), Wilfrid Laurier University, Waterloo, ON, Canada, Dept. of Psychology, Behavioural Neuroscience

Sep ‘08 - Aug ‘10 - M.Sc. (Leri Lab), University of Guelph, Guelph, ON, Canada, Dept. of Psychology, Neuroscience & Applied Cognitive Science / Specialist: Toxicology

Sep ‘04 - May ‘08 - Hon. B.Sc. (Fleming Lab / Gerlai Lab), University of Toronto, Mississauga, ON, Canada, Dept. of Psychology, Specialist: Psychology, Minors: Biology & Physiology

current position

Jul ‘17 - present - Post-Doctoral Associate (Ramirez Lab), Center for Integrated Life Sciences & Engineering, Boston University, Boston, MA, USA, Dept. of Psychological & Brain Sciences, Center for Memory & Brain, Center for Systems Neuroscience

selected past positions

Jan ‘17 - Jul ‘17 - Research Fellow (Ramirez Lab), Centre for Brain Science, Harvard University, Cambridge, MA

Sep ‘10 - Dec ‘11 - Research Assistant (Le Lab), University of Toronto, Centre for Addiction & Mental Health, Toronto, ON

Sep ‘09- Aug ‘10 - Animal Surveillance Technician (Mary Fowler), Animal Care Services, Ontario Veterinary College, University of Guelph, Guelph, ON

Refereed Publications *denotes first-author ** Corresponding author

16. Grella, SL, Fortin AH, McKissick O, & Ramirez S. (in prep). Odor modulates the temporal dynamics of fear memory consolidation.

15. Grella SL, Fortin AH, Bladon JH, McKissick O, Cincotta C, Zaki Y, Leblanc H, Dorst K, Shpokayte M, Doucette E, Merfeld E, & Ramirez, S. (in prep) Reactivating hippocampus-mediated memories to disrupt the reconsolidation of fear.

14. Merfeld E*, Doucette E*, Leblanc H, Cincotta C, Logan J, Monasterio A, Zaki Y, Shpokayte M, Grella SL, & Ramirez S. (submitted) Chronic reactivation of positive and negative memories modulates social and hedonic behavior.

13. Shpokayte S, Liu S, McKissick O, Kramer E, Grella SL, Doucette E, Merfeld E, Jaenisch R, & Ramirez S. (in review) Population and projection-specific segregation of fear and reward engrams.

12. Zaki Y*, Mau W*, Hamidi A, Doucette E, Grella SL, Merfeld E, Murawski NJ, Shpokayte M, & Ramirez S. (in review). Hippocampus and amygdala fear memory engrams re-emerge after contextual fear reinstatement.

11. Chen B*, Murawski NJ*, Cincotta C, McKissick O, Hamidi A, Merfeld E, Doucette E, Grella SL, Shpokayte M, Zaki Y, Fortin AH, & Ramirez, S. (2019) Artificially enhancing and suppressing hippocampus-mediated memories. (in press D-1800929) Current Biology

10. Grella SL**, Neil J, Strong VD, Edison H, Odintsova IV, Martin G, Walling S, Marrone DF, & Harley CW. (2019) Locus coeruleus phasic, but not tonic, activation initiates global remapping in a familiar environment. J. Neurosci 39(3):445-455. J Neurosci featured article

9. Sherry DF, Grella SL, Guigueno MF, White DJ & Marrone DF. (2017) Are there place cells in the avian hippocampus? Brain, Beh & Evol, 90(1) 73-80. Article selected as Karger’s BBE Editor’s Choice

8. Maple AM, Lackie R, Elizalde S, Grella SL, Damphousse CC, Colin X, Gallitano AL, & Marrone DF. (2017) Attenuated late-phase Arc transcription in the dentate gyrus of mice lacking Egr3. Neural Plasticity, Vol 2017, 6063048.

7. Grella SL, Guigueno MF, White DJ, Sherry DF, & Marrone DF. (2016) Context-dependent Egr1 expression in the avian hippocampus. (2016). Plos One, 11(10): e0164333

6. Grella SL, Funk D, Coen K, Li Z, & Lê AD (2014). A stress specific role for the kappa opioid system in the reinstatement of nicotine seeking in rats. Behav Brain Res. 265:188-97.

5. Zhou Y, Leri F, Grella SL, Aldrich JV, & Kreek MJ (2013). Involvement of dynorphin and kappa opioid receptor in yohimbine-induced reinstatement of heroin seeking in rats. Synapse, 67: 358-361.

4. Grella SL, Levy A-M, Campbell A, Djazayeri S, Goddard B, Allen CA, & Leri F (2011). Oxycodone dose-dependently imparts conditioned reinforcing properties to discrete sensory stimuli in rats. Pharmacological Research. 64(4): 364-70.

3. Grella SL, Kapur N, & Gerlai R (2010). A Y-maze choice task fails to detect alcohol avoidance or alcohol preference in zebrafish. International Journal of Comparative Psychology, 23, 26-42.

2. Afonso VM, Grella SL, Chatterjee D, & Fleming AS (2008). Previous maternal experience affects accumbal dopaminergic responses to pup stimuli. Brain Research. 1198, 115-23.

1. Burton CL, Chatterjee D, Chatterjee-Chakraborty M, Lovic V, Grella SL, Steiner M, & Fleming AS (2007) Prenatal restraint stress and motherless rearing disrupts expression of plasticity markers and stress induced corticosterone release in adult female Sprague-Dawley rats. Brain Research. 1158, 28-38.


Refereed Conference Proceedings & Poster Presentations (First Author only)

19. Grella SL, JH, Fortin AF, Zaki Y, Cincotta CR, McKissick OP, Shpokayte M, Doucette E, Merfeld E, & Ramirez S. Perturbation of dorsal hippocampal ensembles disrupts memory stability. SfN Meeting, Chicago, Oct’ 19

18. Grella SL, Fortin AH, Bladon JH, Murawski NJ, Zaki Y, Doucette E, Merfeld E, Shpokayte M, & Ramirez, S. Reactivating hippocampus-mediated memories to disrupt the reconsolidation of fear. SfN Meeting, San Diego: Oct ‘18

17. Grella SL, Fortin AH, Zaki Y, Murawski NJ, Merfeld E, Shpokayte M, & Doucette E, Ramirez, S. Reactivating hippocampus-mediated memories to disrupt the reconsolidation of fear. International Conference on Learning and Memory, Irvine, CA: Apr ‘18

16. Grella SL, Zaki Y, Murawski NJ, Fortin AH, Merfeld E, Shpokayte M, & Doucette E, Ramirez, S. Reactivating hippocampus-mediated memories to disrupt the reconsolidation of fear. SfN Meeting, Washington DC: Nov ‘17 Abstract selected as Hot Topic

15. Grella SL, Neil J, Strong VD, Odintsova IV, Martin G, Harley CW, & Marrone DF. Norepinephrine as a memory reset signal: phasic activation of the locus coeruleus drives global remapping in the hippocampus. Gordon Research Coference: Catecholamines, Newry, ME: Aug ‘17

14. Grella SL, Zaki, Murawski NJ, Doucette E, Merfeld E, Shpokayte M, & Ramirez, S. Reactivating hippocampus-mediated memories to disrupt the reconsolidation of fear. Invited to present at The Boston Area Neuroscience Group, Boston: Jun ‘17

13. Grella SL, Neil J, Strong VD, Odintsova IV, Martin G, Harley CW, & Marrone DF. Norepinephrine as a memory reset signal: phasic activation of the locus coeruleus drives global remapping in the hippocampus. Invited to present at The Evelyn McKnight Brain Institute Social, SfN Meeting, San Diego CA: Nov ‘16

12. Grella SL, Guigueno MF, White DJ, Sherry DF, & Marrone DF. Contextually mediated zenk expression in the hippocampal formation of the male brown-headed cowbird (Molothrus ater). SfN Meeting, Chicago IL: Oct ‘15

11. Grella SL, Guigueno MF, White DJ, Sherry DF, & Marrone DF. Context-specific place-like cells are recruited in the hippocampal formation of the male brown-headed cowbird (Molothrus ater). Southern Ontario Neuroscience Association (SONA) Conference (SfN chapter), Hamilton, ON: May ‘15

10. Grella SL, Neil J, Odintsova I, Martin G, Harley CW, & Marrone DF. Phasic and tonic activation of the locus coeruleus induces global remapping in the dentate gyrus. SfN Meeting, Washington, DC: Nov ‘14

9. Grella SL, Edison HT, Neil J, Odintsova I, Harley CW, & Marrone DF. Phasic and tonic activation of the locus coeruleus induces global remapping in the dentate gyrus. SONA Conference, Western University, London, ON: May ‘14

8. Grella SL, Schmidt BJ, Gomes SM, Satvat E, Argraves M, Markus EJ, & Marrone DF. Arc expression in the prefrontal cortex following shifts in cognitive strategy with a fixed trajectory. SfN Meeting, San Diego, CA: Nov ‘13

7. Grella SL, Schmidt BJ, Satvat E, Argraves M, Markus EJ, & Marrone DF. Prefrontal arc expression during a spatial and non-spatial navigation task with identical trajectory. SfN Meeting, New Orleans, LA: Oct ‘12

6. Grella SL, Ervin K, & Leri F. Factors affecting acute stress-induced reinstatement of heroin seeking in rats. SONA Conference, Brock University, St. Catherines, ON: May 9, ‘10

5. Grella SL, Ervin K, & Leri F. Factors affecting acute stress-induced reinstatement of heroin seeking in rats. Neuroscience Day Arboretum Conference, University of Guelph, Guelph, ON: Apr 9, ‘10

4. Grella SL, Levy A-M, Djazayeri S, & Leri F. Thinking outside the place-conditioning box. Canadian Association for Neurosciences Meeting, Ottawa, ON: May ‘10

3. Grella SL, Allen CP, & Leri F. The effect of acute stress on heroin self-administration after withdrawal and extinction. SfN Meeting, Chicago, IL: Oct ‘09

2. Grella SL & Leri F. The effect of acute stress on reacquisition of heroin self-administration. SONA Conference, McMaster University, Hamilton, ON: May ‘09

1. Grella SL & Leri F. The effect of acute stress on reacquisition of heroin self-administration. Neuroscience Day Arboretum Conference, University of Guelph, Guelph, ON: Apr ‘09

Refereed Conference Proceedings & Poster Presentations (Non-First Author)

20. Finkelstein AB, Hamidi A, Zaki Y, Merfeld E, Grella SL, Murawski NJ, Shpokayte M, & Ramirez S. Manipulating a social ensemble to modulate socially induced reinstatement of a contextual fear memory. SfN Meeting, San Diego: Oct ‘18

19. Cincotta C, Murawski NJ, Grella SL, Doucette E, Merfeld E, Shpokayte M, Zaki Y, Hamidi A, Dorst K, & Ramirez S. Optogenetic induced extinction-like behaviors in ethanol withdrawn mice. SfN Meeting, San Diego: Oct ‘18

18. Shpokayte M, McKissick O, Liu SX, Grella SL, Doucette E, Merfeld E, Murawski NJ, Zaki Y, Finkelstein AB, & Ramirez S. Population and projection-specific segregation of fear and reward in the ventral hippocampus. SfN Meeting, San Diego: Oct ‘18

17. Doucette E, Merfeld E, Logan J, Zaki Y, Grella SL, Murawski NJ, Shpokayte M, Hamidi A, Dorst K, Finkelstein AB & Ramirez, S. Chronically reactivating positive and negative memories to modulate hedonic and social behaviors. SfN Meeting, San Diego: Oct ‘18

16. Mau W, Zaki Y, Hamidi A, Doucette E, Grella SL, Murawski NJ, Merfeld E, Shpokayte M, & Ramirez S. Visualization and modulation of ensembles in the hippocampus and amygdala during fear reinstatement. SfN Meeting, San Diego: Oct ‘18

15. Doucette E, Merfeld E, Zaki Y, Grella SL, Murawski NJ, Shpokayte M, & Ramirez, S. Chronically reactivating positive and negative memories to modulate hedonic and social behaviors. SfN Meeting, Washington DC: Nov ‘17

14. Murawski NJ, Chen B, Grella SL, Shpokayte M, Merfeld E, Zaki Y, Doucette E, & Ramirez, S. Artificially enhancing or suppressing hippocampus-mediated fear memories. SfN Meeting, Washington DC: Nov ‘17

13. Zaki Y, Doucette E, Grella SL, Murawski NJ, Merfeld E, Shpokayte M, & Ramirez, S. Inhibiting ensembles in the hippocampus and amygdala to suppress reinstatement-induced fear. SfN Meeting, Washington DC: Nov ‘17

12. Shpokayte M, Grella SL, Murawski NJ, Zaki Y, Doucette E, Merfeld E, & Ramirez, S. Activating ventral hippocampus to amygdala terminals processing fear and reward. SfN Meeting, Washington DC: Nov ‘17

11. Murawski NJ, Chen B, Grella SL, Shpokayte M, Merfeld E, Zaki Y, Doucette E, & Ramirez S. Artificially enhancing or suppressing hippocampus mediated fear memories. Boston Area Neuroscience Group, Boston: Jun ‘17

10. Zaki Y, Doucette E, Grella SL, Murawski NJ, Merfeld E, Shpokayte M, & Ramirez, S. Inhibiting ensembles in the hippocampus and amygdala to suppress reinstatement-induced fear. Boston Area Neuroscience Group, Boston: Jun ‘17

9. Renda B, Grella SL, Gomes SM, & Marrone DF. Effects of isoproterenol in the dentate gyrus on spatial memory retrieval and reversal learning. SfN Meeting, San Diego CA: Nov ‘16

8. Gallitano AL, Maple AM, Lackie R, Elizalde S, Grella SL, & Marrone DF. Attenuated late-phase Arc transcription in the dentate gyrus of mice lacking Egr3. SfN Meeting, San Diego CA: Nov ‘16

7. Gomes SM, Grella SL, Schmidt BJ, Satvat E, Markus EJ, & Marrone DF. Immediate early gene expression in the prefrontal cortex following contextual alterations and shifts in cognitive strategy. SONA Conference, McMaster University, London, ON: May ‘14

6. Gomes SM, Grella SL, & Marrone DF. The role of norepinephrine in the dentate gyrus of the hippocampus during a delayed-non-match-to-position task involving pattern separation. Stanford Undergraduate Conference, Stanford, CA: May ‘14

5. Lackie R, Grella SL, Gomes SM, & Marrone DF. The role of norepinephrine in the dentate gyrus during a delayed non-match to position task involving pattern separation. SONA Conference, McMaster University, London, ON: May ‘14 Poster award received

4. Gomes SM, Grella SL, Schmidt BJ, Satvat E, Argraves M, Markus EJ, & Marrone DF. Prefrontal arc expression during a spatial and non-spatial navigation task with identical trajectory. SONA Conference, Wilfrid Laurier University, Waterloo, ON: May ‘13

3. Johnson SA, Sediqzadah S, Grella SL, Nobrega JN, & Erb S. Cocaine-associated contextual cues increase c-fos mRNA expression in the basolateral amygdale and prefrontal cortex after extended drug-free periods. SfN Meeting, San Diego, CA: Nov ‘10

2. Afonso V, Grella SL, Chatterjee D, & Fleming AS. Maternal experiences affect mesolimbic dopaminergic neuronal activity in the non-lactating rat: a microdialysis study. Society for Behavioural Neuroendocrinology Meeting, Pittsburgh, PA: Jun ‘06

1. Afonso V, Grella SL, Chatterjee D, & Fleming AS. Maternal experiences affect mesolimbic dopaminergic neuronal activity in the non-lactating rat: a microdialysis study. SfN Meeting, Atlanta, GA: Oct ‘06

Awards & Recognitions

  • Sep ‘17 – Society for Neuroscience Trainee Professional Development Award

  • Dec ‘17 – Student Horizon Fund

  • Apr ‘17 – Dean of Graduate Studies Doctoral Dissertation Award

  • Jan ‘17 – Student Horizon Fund

  • Apr ‘16 - Teaching Assistant Award of Excellence

  • Aug ‘15 - Doctoral Research Travel Award

  • Jun ‘14 – Apr ‘15 - Dean of Graduate & Postdoctoral Studies Scholarship

  • Oct ‘14 – Nov ‘14 - Conference Travel Award

  • Sep ‘14 – Aug ‘17 - Doctoral Fellowship, Ontario Mental Health Foundation (declined)

  • Jul ‘14 – Sep ‘14 - Laurier Graduate Scholarship

  • May ‘14 – Apr ‘16 - Alexander Graham Bell Canadian Graduate Scholarship, National Science & Engineering Research Council

  • Sep ‘13 – Aug ‘14 - Graduate Scholarship

    Oct ‘12 – Nov ‘12 - Conference Travel Award

  • Sep ‘12 – Aug ‘13 - Graduate Scholarship

  • Sep ‘10 – Aug ‘11 - Graduate Scholarship

  • Sep ‘09 – Aug ‘10 - Dean’s Scholarship